The 6-Methylisoquinoline reduction reaction

6-Methylisoquinoline is achromatic crystal, melting point 26.48 ℃, 242.2℃boiling point ( 99.1kPa ), the about body of 1.09101 ( 30/4 ℃), refractive basis 1.62078 ( 30 ℃), beam is 107 ℃. With a array of amoebic solvents miscible, acrid in adulterated acid. With a able acrid absorbent, quinoline. Agnate to anise oil and methyl phenyl ether smell. With the beef can be volatile. Afterwards storage, the blush yellow. PKa=5.4, acrid hardly stronger than quinoline, can become a alkali and acid: its hydrochloride, melting point 209 ℃, melting point 223 ℃picrate. N can action acylation and alkylation reaction, its melting point is 159 ℃methiodide. Electrophilic barter occurs in the 5 or 8 bits. Nucleophilic barter occurs in 1. Susceptible to blaze and abridgement reaction. Found in atramentous tar, authoritative accessible than Zeller - Na Pierre Lars Ki amalgam or Pomerantz - Selfridge reaction. Containing isoquinoline ring some important alkaloids. Isoquinoline agreeable ( and baptize ) chromatography, %, not beneath than 95 water, % of not added than 0.5. Isoquinoline agnate actinic backdrop and pyridine and quinoline, protonation, alkylation, acylation and peracetic acerbic blaze is agitated out in the N atom, electrophilic ambrosial barter and nucleophilic ambrosial barter acknowledgment mainly in the ring of the C atoms on the. Can accomplish drugs and insecticide, blaze can be fabricated afterwards pyridine carboxylic acid, its acquired can be acclimated in the accomplish of blush blur and dye. Acclimated as average and constructed drugs, dyes, pesticides, gas chromatography anchored liquid.

6-Methylisoquinoline is acrid permanganate oxidation, two rings can be degraded, acquired is a admixture of pyridine -3,4- two formic acerbic and the adjoining benzene two formic acid. While in aloof average with potassium permanganate blaze of benzene ring, not alone generation, adjoining benzene two formyl imine. Of substituents on the benzene ring can access the blaze acknowledgment results. With peracetic acerbic blaze of isoquinoline, to isoquinoline N- oxide. Isoquinoline can be catalytic hydrogenation, hydride reagents or metal reduction; aswell can apprehend the careful restore absolutely or partially bargain isoquinoline pyridine ring or ring. Catalytic hydrogenation of the artefact is abundantly afflicted by acerb acknowledgment medium: in acerb acid, pyridine ring careful abridgement of 1,2,3,4- four hydrogen isoquinoline; and in concentrated hydrochloric acid, benzene by careful abridgement of 5,6,7,8- four hydrogen isoquinoline, added abridgement of a admixture of CIS and auto ten hydrogen isoquinoline is generated. Isoquinoline with two ethyl aluminum hydride and lithium aluminium hydride abridgement can get 1,2- two hydrogen isoquinoline actual lively; abridgement by 3,4- two hydrogen isoquinoline with lithium in aqueous ammonia. Isoquinoline onium ions by sodium borohydride in protic solvents rapidly abbreviation 1,2,3,4- generated four hydrogen isoquinoline, the acknowledgment is an important acknowledgment in assurance of alkaloids structure. Heterocyclic atom is fast reduced, added reducible anatomic groups such as carbonyl can be not affected.

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