Synonym: 4’,5,7-Trihydroxyflavone
CAS Number: 520-36-5
Purity: ≥98%
Molecular Weight: 270.24
Molecular Formula: C15H10O5
Solubility: Soluble in DMSO (27 mg/mL) or 1M KOH
(50mg/ml)
Storage: Store at -20° C
Melting Point: >300 °C (lit.)
Boiling Point: 555.51 °C at 760 mmHg
Density: 1.55 g/cm3
Application: An antiinflammatory casein kinase II
inhibitor
Apigenin is an antioxidant
bulb flavonoid which contains antiinflammatory and anticancer properties. It
may abet apoptosis and arrest admeasurement of bump beef by arresting the
corpuscle aeon at the G2/M phase. Apigenin is aswell accepted to be a MAP
kinase inhibitor and a careful inhibitor of casein kinase II (CK2). Apigenin is
able of advance assorted furnishings on a all-inclusive array of atomic
targets. Most furnishings arise to be advised via the abolishment of nitric
oxide synthase-2 (NOS2), Hypoxia-inducible agency 1 α (HIF-1α), lipoxygenase,
cyclooxygenase-2 (COX-2) and vascular endothelial advance agency (VEGF)
expression. Apigenin blocks admeasurement of Wnt-1 transfected cells,
dephosphorylates β-catenin and lowers levels of β-catenin and Dvi.
Additionally, apigenin is an inhibitor of CYP19, CYP2C9, and ERK.
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