Ganciclovir is a constructed
alternation of 2′-deoxy-guanosine. It is aboriginal phosphorylated to ganciclovir
monophosphate by a viral kinase encoded by the cytomegalovirus (CMV) gene UL97
during infection. Subsequently, cellular kinases activate the accumulation of
ganciclovir diphosphate and ganciclovir triphosphate, which is present in
10-fold greater concentrations in CMV or canker canker virus (HSV)-infected
beef than antiseptic cells.
Ganciclovir triphosphate is a
aggressive inhibitor of deoxyguanosine triphosphate (dGTP) assimilation into
DNA and preferentially inhibits viral DNA polymerases added than cellular DNA
polymerases. In addition, ganciclovir triphosphate serves as a poor substrate
for alternation elongation, thereby abolition viral DNA amalgam by a additional
route.
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