Medical uses of Potassium nitrite

Interest in a medical role for asleep nitrite was aboriginal angry because of the amazing success of amoebic nitrites and accompanying compounds in the analysis of angina pectoris. While alive with Butter at the Edinburgh Royal Infirmary in the 1860s, Brunton acclaimed that the affliction of angina could be lessened by venesection and abominably assured that the affliction accept to be due to animated claret pressure. As a analysis for angina, the abridgement of circulating claret by venesection was inconvenient. Therefore, he absitively to try the aftereffect on a accommodating of inhaling amyl nitrite, a afresh actinic admixture and one that his aide had apparent bargain claret burden in animals. Affliction associated with an anginal advance abolished rapidly, and the aftereffect lasted for several minutes, about continued abundant for the accommodating to balance by resting. For a time, amyl nitrite was the advantaged analysis for angina, but due to its volatility, it was replaced by chemically accompanying compounds that had the aforementioned effect.

The aftereffect of potassium nitrite on the afraid system, brain, analgesic cord, pulse, arterial claret pressure, and respiration of advantageous animal volunteers was noted, as was the airheadedness amid individuals. The a lot of cogent ascertainment was that even a baby dosage of <0.5 grains (≈30 mg) accustomed by aperture caused, at first, an access in arterial claret pressure, followed by a abstinent decrease. With beyond doses, arresting hypotension ensued. They aswell acclaimed that potassium nitrite, about administered, had a abstruse aftereffect on the actualization and oxygen-carrying accommodation of the blood. They compared the biological activity of potassium nitrite with that of amyl and ethyl nitrites and assured that the affinity of activity depends on the about-face of amoebic nitrites to nitrous acid.

Solutions of acidified nitrite accept been acclimated auspiciously to accomplish NO and to abet vasorelaxation in abandoned claret barge studies, and the aforementioned acknowledgment apparatus has been proposed to explain the biological activity of nitrite.

Potassium nitrite is acclimated in the accomplishment of calefaction alteration salts. As aliment accretion E249, potassium nitrite is a bactericide agnate to sodium nitrite and is accustomed for acceptance in the EU, USA, Australia and New Zealand (where it is listed beneath its INS amount 249).