Rotenone is an
odorless, colorless, apparent isoflavone acclimated as a broad-spectrum
insecticide, piscicide, and pesticide. It occurs by itself in the seeds and
stems of several plants, such as the jicama backcountry plant, and the roots of
several associates of Fabaceae. It was the aboriginal declared affiliate of the
ancestors of actinic compounds accepted as rotenoids.
Rotenone works by
interfering with the electron carriage alternation in mitochondria. It inhibits
the alteration of electrons from iron-sulfur centers in circuitous I to
ubiquinone. This interferes with NADH during the conception of accessible
cellular activity (ATP). Circuitous I is clumsy to canyon off its electron to
CoQ, creating a back of electrons aural the mitochondrial matrix. Cellular
oxygen is bargain to the radical, creating a acknowledging oxygen species,
which can accident DNA and added apparatus of the mitochondria.
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