What is Eplerenone?

Eplerenone, an aldosterone receptor adversary agnate to spironolactone, has been apparent to aftermath abiding increases in claret renin and serum aldosterone, constant with inhibition of the abrogating authoritative acknowledgment of aldosterone on renin secretion. The consistent added claret renin action and aldosterone circulating levels do not affected the furnishings of eplerenone. Eplerenone selectively binds to recombinant animal mineralocorticoid receptors about to its bounden to recombinant animal glucocorticoid, progesterone and androgen receptors.

Eplerenone binds to the mineralocorticoid receptor and thereby blocks the bounden of aldosterone (component of the renin-angiotensin-aldosterone-system, or RAAS). Aldosterone synthesis, which occurs primarily in the adrenal gland, is articulate by assorted factors, including angiotensin II and non-RAAS mediators such as adrenocorticotropic hormone (ACTH) and potassium. Aldosterone binds to mineralocorticoid receptors in both epithelial (e.g., kidney) and nonepithelial (e.g., heart, claret vessels, and brain) tissues and increases claret burden through consecration of sodium reabsorption and possibly added mechanisms.