Retinyl acetate reproductive and developmental toxicity

Systemic retinyl acetate can abnormally affect the changeable adeptness of animals. Newly weaned macho and changeable rats maintained on a vitamin A amiss diet but supplemented circadian with 1 µg retinyl acetate for 18-22 weeks had bargain changeable achievement due to evolution absorption and sterility.

Oral doses of retinyl acetate can aswell be teratogenic and baleful to embryos, admitting beneath so than tretinoin or isotretinoin. Oral administering of 25,000 to 100,000 IU/kg retinyl acetate to abundant changeable rats delayed the development of their pups, while abundant mice dosed with abstinent or top amounts of retinyl acetate had college absorption ante and fetal malformations/abnormalities. Likewise, abiding assimilation of boundless amounts of retinyl acetate by changeable bodies has the abeyant to could cause bearing defects in kittens.