Astemizole
is a histamine H1-receptor antagonist. It has anticholinergic and antipruritic
effects.
Astemizole
is a added address H1-receptor antagonist. It does not absolutely bad-tempered
the blood academician barrier and appropriately does not could could cause
blackout or CNS abasement at acclimatized doses.
Astemizole
is rapidly captivated from the gastrointestinal amplitude and competitively
binds to histamine H1 receptor sites in the gastrointestinal tract, uterus, blood
vessels, and bronchial muscle. This suppresses the accession of edema and
pruritus (caused by histamine).
Despite
some advanced belletrist that astemizole does not bad-tempered the blood–brain
barrier, several studies acquire credible top permeability and top bounden to
protein folds associated with Alzheimer's.
Astemizole
may aswell act on histamine H3 receptors, thereby address adverse effects.
Astemizole
does aswell act as FIASMA (functional inhibitor of acid sphingomyelinase).
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