What is Busulfan?

CAS: 55-98-1

Molecular Formula:C6H14O6S2

Molecular Weight: 246.29

Busulfan is a bifunctional alkylating agent, accepting a careful immunosuppressive aftereffect on cartilage marrow. It is not a structural analog of the nitrogen mustards. It has been used in the alcohol analysis of abiding myeloid leukemia (myeloid leukemia, chronic), but although appropriate abatement is provided, no abiding absolution is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.

Busulfan is an antineoplastic in the chic of alkylating agents and is used to amusement assorted forms of cancer. Alkylating agents are so called because of their adeptness to add alkyl groups to abounding electronegative groups beneath altitude present in cells. They stop bump advance by cross-linking guanine bases in DNA double-helix strands - anon advancing DNA. This makes the strands clumsy to uncoil and separate. As this is all-important in DNA replication, the beef can no best divide. In addition, these drugs add methyl or added alkyl groups assimilate molecules area they do not accord which in about-face leads to a miscoding of DNA. Alkylating agents are corpuscle cycle-nonspecific and plan by three altered mechanisms, all of which accomplish the aforementioned end aftereffect - disruption of DNA action and corpuscle death. Overexpression of MGST2, a glutathione s-transferase, is anticipation to advise attrition to busulfan. The role of MGST2 in the metabolism of busulfan is alien however.