Valdecoxib (CAS 181695-72-7) Description

CAS Number:      181695-72-7

Purity:    ≥98%

Molecular Weight:     314.36

Molecular Formula:    C16H14N2O3S

Appearance:      Crystalline powder

Physical State:  Solid

Solubility:      Soluble in DMSO (63 mg/ml at 25 °C), ethanol (18 mg/ml at 25 °C), methanol, acetone, and water (0.5 mg/ml).

Melting Point:   170-172 °C

Boiling Point:   ~481.2 °C at 760 mmHg (Predicted)

Density:   ~1.3 g/cm3 (Predicted)

Application:     A selective inhibitor of Cox-2

Storage:   Store at 4° C

Description:

Valdecoxib is a prescription NSAID exhibiting anti-inflammatory, analgesic, and antipyretic properties. Valdecoxib inhibits prostaglandin synthesis via Cox-2 inhibition and is used in the treatment of osteoarthritis and theumatoid arthritis. Valdecoxib selectively inhibits Cox-2 (IC50 of 0.005 μM) over Cox-1 (IC50 of 140 μM).

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Pharmaceutical Ingredients