Colistin sulfate (CAS 1264-72-8) Description

Synonym:                         Belcomycin; Polymixin E Sulfate

CAS Number:                      1264-72-8

Purity:                          Mixture of >30 compounds, primarily colistin A and B

Molecular Weight:                1267.55

Molecular Formula:               C53H102N16O17S

Solubility:                      Soluble in water (50mg/ml)

Boiling Point:                   1537.3° C

Application:                     A Polymyxin potent antibiotic and apoptosis inducer

Storage:                         Store at -20° C

Description:

Colistin sulfate, a cationic polypeptide from the polymyxin family, has been shown to be an extremely potent antibiotic that is effective against most gram-negative Bacilli. Mechanistic studies have reported that this compound induces apoptosis through interaction with the cytoplasmic membrane. Additional studies have demonstrated that Colistin sulphate is extremely toxic. Toxic effects noted include neurotoxicity, nephrotoxicity, vascular congestion of brain vessels, and extreme kidney and CNS negative effects.