An RNA amalgam inhibitor that is acclimated as an antiviral abettor in the
prophylaxis and analysis of influenza.
Rimantadine, a circadian amine, is a constructed antiviral biologic and a
acquired of adamantane, like a agnate biologic amantadine. Rimantadine is
inhibitory to the in vitro archetype of affliction A virus isolates from
anniversary of the three antigenic subtypes (H1N1, H2H2 and H3N2) that accept
been atapeoned from man. Rimantadine has little or no activity adjoin affliction
B virus. Rimantadine does not arise to baffle with the immunogenicity of
inactivated affliction A vaccine.
The apparatus of activity of rimantadine is not absolutely understood.
Rimantadine appears to apply its inhibitory aftereffect aboriginal in the viral
replicative cycle, possibly inhibiting the uncoating of the virus. Genetic
studies advance that a virus protein defined by the virion M2 gene plays an
important role in the susceptibility of affliction A virus to inhibition by
rimantadine.
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